Reply 1988 tells the story of five friends who have been raised together in the small neighborhood alley of Ssangmun-dong in Seoul. It unfolds a timeline that begins in 1988 and the succeeding years after until 1995 including some snippets of selected characters in 2016. Compared to other dramas that centers on a single character, Reply 1988 gravitates around the five families whose lives are so intertwined with each other.